Preface
Acknowledgments
Section I General Principles 1
1. Drug Invention and the Pharmaceutical Industry
2. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination
3. Pharmacodynamics: Molecular Mechanisms of Drug Action
4. Drug Toxicity and Poisoning
5. Membrane Transporters and Drug Response
6. Drug Metabolism
7. Pharmacogenetics
Section II Neuropharmacology
8. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems
9. Muscarinic Receptor Agonists and Antagonists
10. Anticholinesterase Agents
11. Nicotine and Agents Acting at the Neuromuscular Junction and Autonomic Ganglia
12. Adrenergic Agonists and Antagonists
13. 5-Hydroxytryptamine (Serotonin) and Dopamine
14. Neurotransmission in the Central Nervous System
15. Drug Therapy of Depression and Anxiety Disorders
16. Pharmacotherapy of Psychosis and Mania
17. Pharmacotherapy of the Epilepsies
18. Treatment of Central Nervous System Degenerative Disorders
19. Hypnotics and Sedatives
20. Opioids, Analgesia, and Pain Management
21. General Anesthetics and Therapeutic Gases
22. Local Anesthetics
23. Ethanol
24. Drug Use Disorders and Addiction
Section III Modulation of Pulmonary, Renal, and Cardiovascular Function
25. Drugs Affecting Renal Excretory Function
26. Renin and Angiotensin
27. Treatment of Ischemic Heart Disease
28. Treatment of Hypertension
29. Therapy of Heart Failure
30. Antiarrhythmic Drugs
31. Treatment of Pulmonary Arterial Hypertension
32. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs
33. Drug Therapy for Dyslipidemias
Section IV Inflammation, Immunomodulation, and Hematopoiesis
34. Introduction to Immunity and Inflammation
35. Immunosuppressants and Tolerogens
36. Immune Globulins and Vaccines
37. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor
38. Pharmacotherapy of Inflammation, Fever, Pain, and Gout
39. Histamine, Bradykinin, and Their Antagonists
40. Pulmonary Pharmacology
41. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins
Section V Hormones and Hormone Antagonists
42. Introduction to Endocrinology: The Hypothalamic-Pituitary Axis
43. Thyroid and Antithyroid Drugs
44. Estrogens, Progestins, and the Female Reproductive Tract
45. Androgens and the Male Reproductive Tract
46. Adrenocorticotropic Hormone, Adrenal Steroids, and the Adrenal Cortex
47. Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia
48. Agents Affecting Mineral Ion Homeostasis and Bone Turnover
Section VI Gastrointestinal Pharmacology
49. Pharmacotherapy for Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease
50. Gastrointestinal Motility and Water Flux, Emesis, and Biliary and Pancreatic Disease
51. Pharmacotherapy of Inflammatory Bowel Disease
Section VII Chemotherapy of Infectious Diseases
52. General Principles of Antimicrobial Therapy
53. Chemotherapy of Malaria
54. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections
55. Chemotherapy of Helminth Infections
56. Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections
57. Penicillins, Cephalosporins, and Other ß-Lactam Antibiotics
58. Aminoglycosides
59. Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents
60. Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy
61. Antifungal Agents
62. Antiviral Agents (Nonretroviral)
63. Treatment of Viral Hepatitis (HBV/HCV)
64. Antiretroviral Agents and Treatment of HIV Infection
Section VIII Pharmacotherapy of Neoplastic Disease
65. General Principles in the Pharmacotherapy of Cancer
66. Cytotoxic Drugs
67. Pathway-Targeted Therapies: Monoclonal Antibodies, Protein Kinase Inhibitors, and Various Small Molecules
68. Hormones and Related Agents in the Therapy of Cancer
Section IX Special Systems Pharmacology
69. Ocular Pharmacology
70. Dermatological Pharmacology
71. Environmental Toxicology: Carcinogens and Heavy Metals
Appendices
I. Principles of Prescription Order Writing and Patient Compliance
II. Design and Optimization of Dosage Regimens: Pharmacokinetic Data
Index