Pharmaceutical Preformulation and Formulation: A Practical Guide from Candidate Drug Selection to Commercial Dosage Form

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Edition: 2nd
Format: Hardcover
Pub. Date: 2009-06-23
Publisher(s): CRC Press
List Price: $246.09

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Summary

This timely Second Edition reflects the mounting pressure on pharmaceutical companies to accelerate the new drug development and launch process, and the shift from developing small molecules to the growth of biopharmaceuticals. It meets the need for up-to-date and advanced information for drug preformulation and formulation, and addresses the current trends in the continually evolving pharmaceutical industry.Ideal for practitioners working in the pharmaceutical industry (including R&D scientists, technicians, and managers), as well as undergraduate and postgraduate courses in industrial pharmacy and pharmaceutical technology, this text addresses:candidate drug selection drug discovery and development preformulation predictions and drug selections product design to commercial dosage form biopharmaceutical support in formulation development and more

Author Biography

Mark Gibson, Bpharm, Ph.D., CChem, MRSC, MRpharmS, is responsible for product development of New Molecular Entities and New Product Opportunities at AstraZeneca RD Charnwood, Leicestershire, UK. His experience encompasses 25 years in the pharmaceutical industry, both as a bench scientist and a manager, at Cyanamid (Lederle), Fisons Pharmaceuticals, Astra Pharmaceuticals, and AstraZeneca. He has worked on a wide variety of dosage forms and routes of delivery, including inhalation, oral, nasal, opthalmic, parenteral, and transdermal, some of which have resulted in patents and marketable products. Dr Gibson is a member of the Royal Pharmaceutical Society, the Royal Society of Chemistry, the UK Academy of Pharmaceutical Sciences, and the Parenteral Drug Association.

Table of Contents

Prefacep. vii
Contributorsp. xi
Introduction and Perspectivep. 1
Aiding Candidate Drug Selection: Introduction and Objectivesp. 11
Preformulation Investigations using Small Amounts of Compound as an Aid to Candidate Drug Selection and Early Developmentp. 17
Biopharmaceutical Support in Candidate Drug Selectionp. 129
Early Drug Development: Product Designp. 172
Preformulation as an Aid to Product Design in Early Drug Developmentp. 188
Biopharmaceutical Support in Formulation Developmentp. 247
Product Optimizationp. 289
Parenteral Dosage Formsp. 325
Inhalation Dosage Formsp. 348
Oral Solid Dosage Formsp. 367
Opthalmic Dosage Formsp. 431
Aqueous Nasal Dosage Formsp. 456
Topical and Transdermal Deliveryp. 475
Indexp. 527
Table of Contents provided by Ingram. All Rights Reserved.

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