Respiratory Control and Disorders in the Newborn

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Format: Hardcover
Pub. Date: 2003-01-28
Publisher(s): CRC Press
List Price: $224.69

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Summary

This text analyses the pathophysiology, diagnosis, treatment and control of respiratory disorders in the newborn infant. It explores the mechanisms, patterns, and factors influencing respiratory activity and dysfunction, as well as the aetiology, management, and evaluation of conditions such as respiratory distress syndrome, bronchopulmonary dysplasia, airway disorders, and congenital hypoventilation syndromes.

Table of Contents

Introduction v
Claude Lenfant
Preface vii
Contributors ix
Respiratory Control in the Newborn: Comparative Physiology and Clinical Disorders
1(16)
Gabriel G. Haddad
Introduction
1(1)
Overall Concepts of Respiratory Control
2(4)
The Newborn's Respiratory Control in Perspective
6(5)
Disease States
11(2)
Summary
13(4)
References
13(4)
Gasping and Autoresuscitation
17(22)
Walter M. St.-John
Introduction
17(1)
Elicitation of Gasping
18(1)
Characteristics of Gasping
19(5)
Effectiveness of Gasping in Autoresuscitation
24(1)
Failure of Gasping in Autoresuscitation
24(1)
Critical Region for Neurogenesis of Gasping
25(2)
Mechanisms for the Neurogenesis of Gasping
27(5)
Summary
32(7)
References
33(6)
Ontogeny of Upper- and Lower-Airway Innervation
39(44)
John T. Fisher
Cyril E. Schweitzer
Markus Weichselbaum
Malcolm P. Sparrow
Introduction
39(1)
Anatomy, Morphology, and Distribution
40(21)
Neurophysiologic Behavior of Airway Afferents
61(22)
References
73(10)
Chemical Control of Breathing from Fetal Through Newborn Life
83(32)
Martha Jane Miller
Musa A. Haxhiu
Richard J. Martin
Introduction
83(1)
Development of Chemoreception
83(2)
Maturation of Chemoreceptor Responses to CO2/H+
85(9)
Chemoreceptors for Oxygen and Their Role in Breathing
94(21)
References
103(12)
Upper-Airway Muscle Control During Development: Application to Clinical Disorders That Occur in Premature Infants
115(34)
Estelle B. Gauda
Introduction
115(2)
Apnea in Premature Infants: Incidence and Characterization
117(1)
Pharynx: A Site of Upper-Airway Obstruction and the Role of Pharyngeal Dilator Muscles in Apnea
118(1)
Brainstem Neuronal Network Responsible for Respiratory Rhythmogenesis
119(2)
Hypoglossal Motoneurons During Postnatal Development
121(3)
Upper-Airway Muscle Atonia During Sleep: Role of TRH, NE, and 5HT
124(1)
Infants with BPD Have Increased Frequency of Apnea: Possible Mechanisms
125(5)
The Larynx: A Site of Upper-Airway Obstruction During Apnea in Premature Infants
130(1)
Role of Laryngeal Receptors in Modulation of Upper-Airway Muscle Responses
130(4)
Why Therapies Are Effective in Treating Apnea in Premature Infants
134(2)
Conclusions
136(13)
References
137(12)
Developmental Trend of Sleep Characteristics in Premature and Full-Term Newborns
149(34)
Lilia Curzi-Dascalova
Introduction
149(1)
Development of Behavioral States in Animals
150(2)
Behavioral States in Early Human Ontogenesis
152(12)
Neurophysiological Correlates of Sleep States in Premature and Full-Term Newborns
164(6)
Comments and Summary
170(13)
References
173(10)
Metabolic and Ventilatory Interaction in the Newborn
183(26)
Jacopo P. Mortola
Introduction
183(1)
Glossary of Terms and Definitions
184(1)
Interspecies Differences in Metabolic Rate
185(1)
Metabolic Rate During Body Growth and Aging
186(1)
Circadian Patterns of Metabolism
187(2)
Changes in Temperature
189(3)
Changes in Respiratory Gases
192(7)
Extrapulmonary Gas Exchange
199(2)
Summary and Concluding Remarks
201(8)
References
203(6)
Respiratory Control Disorders: An Overview
209(8)
Oommen P. Mathew
Introduction
209(1)
Respiratory Control Disorders
209(3)
Assessment of Respiratory Control Disorders
212(2)
Summary
214(3)
References
215(2)
Monitoring in the NICU
217(20)
Christian F. Poets
Introduction
217(1)
Electrocardiography (ECG) and Heart Rate Monitoring
217(1)
Monitoring of Chest Wall Movements
218(1)
Transcutaneous Partial Pressure of Oxygen (PTcCO2) Monitoring
219(2)
Pulse Oximetry (SPO2)
221(4)
Transcutaneous Partial Pressure of Carbon Dioxide (PTcCO2) Monitoring
225(1)
End-Tidal Carbon Dioxide (ETCO2) Monitoring (Capnometry)
226(3)
False Alarms in the NICU
229(1)
Alarm Settings
230(7)
References
231(6)
Periodic Breathing
237(36)
Henrique Rigatto
Introduction
237(1)
Concept, Morphology, and Prevalence
237(3)
History
240(1)
Mechanisms of Periodic Breathing
241(13)
The Clinical Scenario
254(4)
Clinical Significance in Neonates
258(3)
Long-Term Developmental Speculation
261(12)
References
262(11)
Apnea, Bradycardia, and Desaturation: Clinical Issues
273(22)
Oommen P. Mathew
Introduction
273(1)
Definition and Classification
273(4)
Differential Diagnosis
277(4)
Time of Occurrence
281(1)
Significance of Sequence of Events
282(2)
Episodic Bradycardia and Desaturation Among Intubated Infants
284(2)
Apnea and Neurodevelopmental Outcome
286(1)
Summary
287(8)
References
288(7)
Pathophysiology of Apnea of Prematurity: Implications from Observational Studies
295(22)
Christian F. Poets
Introduction
295(1)
Relationship Between Apnea, Bradycardia, and Desaturation
295(3)
Changes in Lung Volume During Apnea
298(1)
Role of Feeding and Gastroesophageal Reflux
299(3)
Chest Wall Distortion, Anatomical Dead Space, and Diaphragmatic Fatigue
302(2)
Upper-Airway Obstruction
304(2)
Hypoxic Ventilatory Depression
306(2)
Anemia
308(1)
Termination of Apnea
309(1)
Conclusion
310(7)
References
310(7)
Pharmacotherapy of Apnea of Prematurity
317(18)
Alison Graham
Neil N. Finer
Introduction
317(1)
Theophylline
317(3)
Caffeine
320(3)
Doxapram
323(2)
Gastroesophageal Reflux and Apnea
325(1)
Conclusion
326(9)
References
327(8)
Nonpharmacological Management of Idiopathic Apnea of the Premature Infant
335(20)
Edward E. Lawson
Introduction
335(1)
Positioning
336(2)
Nonpharmacological Mechanisms to Stimulate the Central Nervous System
338(4)
Thermal Environment
342(1)
Oxygen
343(3)
Mechanical Airway Support
346(3)
Concluding Remarks
349(6)
References
349(6)
Maturation of Respiratory Control
355(18)
Eric C. Eichenwald
Ann R. Stark
Introduction
355(1)
Sleep and Breathing
356(4)
Maturation of Neuromuscular Reflex Responses
360(5)
Maturation of Respiratory Control: Resolution of Apnea of Prematurity
365(3)
Conclusions
368(5)
References
368(5)
Respiratory Control During Oral Feeding
373(22)
Oommen P. Mathew
Introduction
373(1)
Sucking
374(2)
Swallowing
376(2)
Breathing
378(6)
Disorders of Breathing During Feeding
384(3)
Maturation
387(1)
Summary
388(7)
References
388(7)
Idiopathic Congenital Central Hypoventilation Syndrome
395(14)
Debra E. Weese-Mayer
Jean M. Silvestri
Introduction
395(1)
Differential Diagnosis
395(1)
Initial Evaluation
396(1)
Control of Breathing Deficit
396(1)
Associated Conditions
397(1)
Autonomic Nervous System Dysfunction in CCHS
397(1)
Familial Occurrence of CCHS
398(1)
Familial Occurrence of ANSD
399(1)
Ventilatory Support Options
400(2)
Long-Term Comprehensive Management
402(1)
Long-Term Outcome
402(1)
Key to the Successful Management of the Child with CCHS
403(1)
Limitations to Optimal Care for the Child with CCHS
404(5)
References
404(5)
Regulation of Breathing in Neuromuscular Diseases
409(18)
Oommen P. Mathew
Introduction
409(2)
Central Nervous System
411(2)
Anterior Horn Cells
413(2)
Nerves, Neuromuscular Junction, and Muscles
415(4)
Summary
419(8)
References
420(7)
Regulation of Breathing in Acute Ventilatory Failure
427(24)
Anne Greenough
Introduction
427(1)
Respiratory Activity During Mechanical Ventilation
427(4)
Respiratory Reflexes
431(2)
Factors Influencing Respiratory Activity
433(9)
Methods of Detecting Respiratory Activity During Mechanical Ventilation
442(2)
Influence of Respiratory Activity on the Outcome of Mechanical Ventilation for Acute Ventilatory Failure
444(7)
References
444(7)
Respiratory Control in Bronchopulmonary Dysplasia
451(22)
Miriam Katz-Salamon
Introduction
451(1)
Definition and Etiology
452(1)
Control of Breathing in BPD
453(4)
Relationships Between Control of Heart Rate and Respiration
457(2)
Hypoxemia in BPD
459(2)
Respiration During Sleep in BPD
461(2)
Respiratory Sequelae in BPD Infants
463(1)
Short- and Long-Term Neuromotor and Cognitive Development
464(1)
Conclusions
465(8)
References
465(8)
Gastroesophageal Reflux and Related Diseases
473(22)
Taher Omari
Introduction
473(1)
Gastrointestinal Motility
474(3)
Gastroesophageal Reflux
477(6)
Pathophysiology of GER Disease
483(3)
Respiratory Disease and GER
486(9)
References
490(5)
Airway Disorders in the Newborn
495(30)
Oommen P. Mathew
Introduction
495(1)
Maintenance of Airway Patency
495(4)
Airway Imaging Studies
499(2)
Disorders of Airway Patency
501(16)
Summary
517(8)
References
517(8)
SIDS and the Newborn Infant
525(16)
Jean M. Silvestri
Debra E. Weese-Mayer
Introduction
525(1)
Definition and Risk Factors
525(1)
Age at Presentation
526(1)
Gestational Age
526(1)
Modifiable Risk Factors for SIDS
527(7)
Summary
534(7)
References
535(6)
Author Index 541(58)
Subject Index 599

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