Introduction |
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v | |
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Preface |
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vii | |
Contributors |
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ix | |
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Respiratory Control in the Newborn: Comparative Physiology and Clinical Disorders |
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1 | (16) |
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1 | (1) |
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Overall Concepts of Respiratory Control |
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2 | (4) |
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The Newborn's Respiratory Control in Perspective |
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6 | (5) |
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11 | (2) |
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13 | (4) |
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13 | (4) |
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Gasping and Autoresuscitation |
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17 | (22) |
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17 | (1) |
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18 | (1) |
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Characteristics of Gasping |
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19 | (5) |
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Effectiveness of Gasping in Autoresuscitation |
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24 | (1) |
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Failure of Gasping in Autoresuscitation |
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24 | (1) |
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Critical Region for Neurogenesis of Gasping |
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25 | (2) |
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Mechanisms for the Neurogenesis of Gasping |
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27 | (5) |
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32 | (7) |
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33 | (6) |
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Ontogeny of Upper- and Lower-Airway Innervation |
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39 | (44) |
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39 | (1) |
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Anatomy, Morphology, and Distribution |
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40 | (21) |
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Neurophysiologic Behavior of Airway Afferents |
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61 | (22) |
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73 | (10) |
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Chemical Control of Breathing from Fetal Through Newborn Life |
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83 | (32) |
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83 | (1) |
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Development of Chemoreception |
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83 | (2) |
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Maturation of Chemoreceptor Responses to CO2/H+ |
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85 | (9) |
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Chemoreceptors for Oxygen and Their Role in Breathing |
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94 | (21) |
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103 | (12) |
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Upper-Airway Muscle Control During Development: Application to Clinical Disorders That Occur in Premature Infants |
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115 | (34) |
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115 | (2) |
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Apnea in Premature Infants: Incidence and Characterization |
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117 | (1) |
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Pharynx: A Site of Upper-Airway Obstruction and the Role of Pharyngeal Dilator Muscles in Apnea |
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118 | (1) |
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Brainstem Neuronal Network Responsible for Respiratory Rhythmogenesis |
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119 | (2) |
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Hypoglossal Motoneurons During Postnatal Development |
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121 | (3) |
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Upper-Airway Muscle Atonia During Sleep: Role of TRH, NE, and 5HT |
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124 | (1) |
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Infants with BPD Have Increased Frequency of Apnea: Possible Mechanisms |
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125 | (5) |
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The Larynx: A Site of Upper-Airway Obstruction During Apnea in Premature Infants |
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130 | (1) |
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Role of Laryngeal Receptors in Modulation of Upper-Airway Muscle Responses |
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130 | (4) |
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Why Therapies Are Effective in Treating Apnea in Premature Infants |
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134 | (2) |
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136 | (13) |
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137 | (12) |
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Developmental Trend of Sleep Characteristics in Premature and Full-Term Newborns |
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149 | (34) |
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149 | (1) |
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Development of Behavioral States in Animals |
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150 | (2) |
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Behavioral States in Early Human Ontogenesis |
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152 | (12) |
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Neurophysiological Correlates of Sleep States in Premature and Full-Term Newborns |
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164 | (6) |
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170 | (13) |
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173 | (10) |
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Metabolic and Ventilatory Interaction in the Newborn |
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183 | (26) |
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183 | (1) |
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Glossary of Terms and Definitions |
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184 | (1) |
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Interspecies Differences in Metabolic Rate |
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185 | (1) |
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Metabolic Rate During Body Growth and Aging |
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186 | (1) |
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Circadian Patterns of Metabolism |
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187 | (2) |
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189 | (3) |
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Changes in Respiratory Gases |
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192 | (7) |
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Extrapulmonary Gas Exchange |
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199 | (2) |
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Summary and Concluding Remarks |
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201 | (8) |
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203 | (6) |
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Respiratory Control Disorders: An Overview |
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209 | (8) |
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209 | (1) |
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Respiratory Control Disorders |
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209 | (3) |
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Assessment of Respiratory Control Disorders |
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212 | (2) |
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214 | (3) |
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215 | (2) |
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217 | (20) |
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217 | (1) |
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Electrocardiography (ECG) and Heart Rate Monitoring |
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217 | (1) |
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Monitoring of Chest Wall Movements |
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218 | (1) |
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Transcutaneous Partial Pressure of Oxygen (PTcCO2) Monitoring |
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219 | (2) |
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221 | (4) |
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Transcutaneous Partial Pressure of Carbon Dioxide (PTcCO2) Monitoring |
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225 | (1) |
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End-Tidal Carbon Dioxide (ETCO2) Monitoring (Capnometry) |
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226 | (3) |
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229 | (1) |
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230 | (7) |
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231 | (6) |
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237 | (36) |
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237 | (1) |
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Concept, Morphology, and Prevalence |
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237 | (3) |
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240 | (1) |
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Mechanisms of Periodic Breathing |
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241 | (13) |
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254 | (4) |
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Clinical Significance in Neonates |
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258 | (3) |
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Long-Term Developmental Speculation |
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261 | (12) |
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262 | (11) |
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Apnea, Bradycardia, and Desaturation: Clinical Issues |
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273 | (22) |
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273 | (1) |
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Definition and Classification |
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273 | (4) |
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277 | (4) |
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281 | (1) |
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Significance of Sequence of Events |
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282 | (2) |
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Episodic Bradycardia and Desaturation Among Intubated Infants |
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284 | (2) |
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Apnea and Neurodevelopmental Outcome |
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286 | (1) |
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287 | (8) |
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288 | (7) |
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Pathophysiology of Apnea of Prematurity: Implications from Observational Studies |
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295 | (22) |
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295 | (1) |
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Relationship Between Apnea, Bradycardia, and Desaturation |
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295 | (3) |
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Changes in Lung Volume During Apnea |
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298 | (1) |
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Role of Feeding and Gastroesophageal Reflux |
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299 | (3) |
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Chest Wall Distortion, Anatomical Dead Space, and Diaphragmatic Fatigue |
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302 | (2) |
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304 | (2) |
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Hypoxic Ventilatory Depression |
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306 | (2) |
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308 | (1) |
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309 | (1) |
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310 | (7) |
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310 | (7) |
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Pharmacotherapy of Apnea of Prematurity |
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317 | (18) |
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317 | (1) |
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317 | (3) |
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320 | (3) |
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323 | (2) |
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Gastroesophageal Reflux and Apnea |
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325 | (1) |
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326 | (9) |
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327 | (8) |
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Nonpharmacological Management of Idiopathic Apnea of the Premature Infant |
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335 | (20) |
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335 | (1) |
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336 | (2) |
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Nonpharmacological Mechanisms to Stimulate the Central Nervous System |
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338 | (4) |
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342 | (1) |
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343 | (3) |
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Mechanical Airway Support |
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346 | (3) |
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349 | (6) |
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349 | (6) |
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Maturation of Respiratory Control |
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355 | (18) |
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355 | (1) |
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356 | (4) |
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Maturation of Neuromuscular Reflex Responses |
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360 | (5) |
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Maturation of Respiratory Control: Resolution of Apnea of Prematurity |
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365 | (3) |
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368 | (5) |
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368 | (5) |
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Respiratory Control During Oral Feeding |
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373 | (22) |
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373 | (1) |
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374 | (2) |
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376 | (2) |
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378 | (6) |
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Disorders of Breathing During Feeding |
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384 | (3) |
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387 | (1) |
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388 | (7) |
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388 | (7) |
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Idiopathic Congenital Central Hypoventilation Syndrome |
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395 | (14) |
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395 | (1) |
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395 | (1) |
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396 | (1) |
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Control of Breathing Deficit |
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396 | (1) |
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397 | (1) |
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Autonomic Nervous System Dysfunction in CCHS |
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397 | (1) |
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Familial Occurrence of CCHS |
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398 | (1) |
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Familial Occurrence of ANSD |
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399 | (1) |
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Ventilatory Support Options |
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400 | (2) |
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Long-Term Comprehensive Management |
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402 | (1) |
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402 | (1) |
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Key to the Successful Management of the Child with CCHS |
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403 | (1) |
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Limitations to Optimal Care for the Child with CCHS |
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404 | (5) |
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404 | (5) |
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Regulation of Breathing in Neuromuscular Diseases |
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409 | (18) |
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409 | (2) |
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411 | (2) |
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413 | (2) |
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Nerves, Neuromuscular Junction, and Muscles |
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415 | (4) |
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419 | (8) |
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420 | (7) |
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Regulation of Breathing in Acute Ventilatory Failure |
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427 | (24) |
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427 | (1) |
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Respiratory Activity During Mechanical Ventilation |
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427 | (4) |
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431 | (2) |
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Factors Influencing Respiratory Activity |
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433 | (9) |
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Methods of Detecting Respiratory Activity During Mechanical Ventilation |
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442 | (2) |
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Influence of Respiratory Activity on the Outcome of Mechanical Ventilation for Acute Ventilatory Failure |
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444 | (7) |
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444 | (7) |
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Respiratory Control in Bronchopulmonary Dysplasia |
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451 | (22) |
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451 | (1) |
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452 | (1) |
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Control of Breathing in BPD |
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453 | (4) |
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Relationships Between Control of Heart Rate and Respiration |
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457 | (2) |
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459 | (2) |
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Respiration During Sleep in BPD |
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461 | (2) |
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Respiratory Sequelae in BPD Infants |
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463 | (1) |
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Short- and Long-Term Neuromotor and Cognitive Development |
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464 | (1) |
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465 | (8) |
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465 | (8) |
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Gastroesophageal Reflux and Related Diseases |
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473 | (22) |
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473 | (1) |
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Gastrointestinal Motility |
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474 | (3) |
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477 | (6) |
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Pathophysiology of GER Disease |
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483 | (3) |
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Respiratory Disease and GER |
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486 | (9) |
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490 | (5) |
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Airway Disorders in the Newborn |
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495 | (30) |
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495 | (1) |
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Maintenance of Airway Patency |
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495 | (4) |
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499 | (2) |
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Disorders of Airway Patency |
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501 | (16) |
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517 | (8) |
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517 | (8) |
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SIDS and the Newborn Infant |
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525 | (16) |
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525 | (1) |
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Definition and Risk Factors |
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525 | (1) |
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526 | (1) |
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526 | (1) |
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Modifiable Risk Factors for SIDS |
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527 | (7) |
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534 | (7) |
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535 | (6) |
Author Index |
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541 | (58) |
Subject Index |
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599 | |